Marquette forward Steve Novak was an unknown freshman when he entered Saturday's game with 19.7 seconds to go in regulation.
He left Indianapolis as the perfect complement.
Novak made three three-pointers and the Golden Eagles hit all of their shots in overtime to pull away from Missouri 101-92 and reach the Midwest Regional semifinals.
Novak came into the game only after starting forward senior Robert Jackson fouled out and scored nine of his 14 points in the final five minutes to lead the third-seeded Golden Eagles (25-5) into the round of 16 for the first time since 1994.
It is only the second time Marquette has advanced beyond the second round since Al McGuire coached the team to the 1977 national championship.
Sophomore guard Travis Diener finished with 26 points and five three-pointers, while junior guard Dwayne Wade had 24 points, eight rebounds and seven assists.
Their performances offset Missouri's one-two punch of junior guard Rickey Paulding and junior center Arthur Johnson. Paulding scored 36 points and made nine three-pointers while Johnson added 28 points and 18 rebounds.
The Golden Eagles will face the No. 2 seed Pittsburgh on Thursday in Minneapolis for the Midwest Regional semifinals.